Peyronie's disease is marked by the formation of fibrous plaques within the tunica albuginea, the connective tissue surrounding the penile corpora cavernosa. These plaques cause an uneven distribution of penile tissue, leading to curvature during an erection. The disease often results in pain, reduced sexual function, and psychological distress. The exact cause of plaque formation is not fully understood, but it is thought to involve trauma to the penis, genetic factors, or collagen abnormalities.
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