Cryo-electron microscopy (Cryo-EM) is a popular method for studying the ultrastructure of biological entities by rapidly freezing samples and irradiating them with electrons. Through electron scattering detection and computer reconstruction, sample structures can be determined. It's seen as an alternative to X-ray crystallography for exploring new targets. However, achieving high-resolution structures with Cryo-EM relies on obtaining high-quality protein samples and establishing necessary infrastructure for method feasibility assessment.
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